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Author Title Journal PMID Products
Jung, H., Shimatani, Y., Hasan, M., Uno, K., Hama, S., & Kogure, K. Development of flexible nanocarriers for siRNA delivery into tumor tissue. Int J Pharm 2016 Nov 18 NCP
Costa EC, Moreira AF, de Melo-Diogo D, Gaspar VM, Carvalho MP, Correia IJ. 3D tumor spheroids: an overview on the tools and techniques used for their analysis. Biotechnol Adv. 2016 Nov 11. pii: S0734-9750(16)30137-9. 27845258 NCP(Review: 3D method)
Iles LR, Bartholomeusz GA. Three-Dimensional Spheroid Cell Culture Model for Target Identification Utilizing High-Throughput RNAi Screens. Methods Mol Biol. 2016;1470:121-35. 27581289 NCP(screening POC)
Heidari Kani M, Chan EC, Young RC, Butler T, Smith R, Paul JW. 3D Cell Culturing and Possibilities for Myometrial Tissue Engineering. Ann Biomed Eng. 2016 Oct 21. 27770218 NCP(Review: 3D method)
Arai K, Egichi T, Rahman MM, Sakamoto R, Masuda N, Nakatsura T, Calderwood, SK, Kozaki K, Itoh M. A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516 PLOS ONE 2016 Sep 13 27622654 NCP, Hypoxia Probe
Yamashita Y, Asakura M, Mitsugi R, Fujii H, Nagai K, Atsuda K, Itoh T, Fujiwara R. MicroRNA expression in the vildagliptin-treated two- and three-dimensional HepG2 cells. Drug Metab Pharmacokinet. 2016 Jun;31(3):201-9. 27209165 NCD
Wang Z, Hu P, Tang F, Lian H, Chen X, Zhang Y, He X, Liu W, Xie C. HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma. Cancer Lett. 2016 Aug 28;379(1):134-42. 27267806 NCP
Yoshii Y, Furukawa T, Aoyama H, Adachi N, Zhang MR, Wakizaka H, Fujibayashi Y, Saga T. Regorafenib as a potential adjuvant chemotherapy agent in disseminated small colon cancer: Drug selection outcome of a novel screening system using nanoimprinting 3-dimensional culture with HCT116-RFP cells. Int J Oncol. 2016 Apr;48(4):1477-84. 26820693 NCP
Yasunari Yamashita, Mitsutoshi Asakuraa, b, Ryo Mitsugia, Hideaki Fujiic, Kenichiro Nagaid, Koichiro Atsudab, Tomoo Itoha, Ryoichi Fujiwara, MicroRNA expression in the vildagliptin-treated two- and three-dimensional HepG2 cells. Drug Metabolism and Pharmacokinetics. 2016 Mar 4
Kagiya G, Ogawa R, Hyodo F, Yamashita K, Nakamura M, Ishii A, Sejimo Y, Tominaga S, Murata M, Tanaka Y, Hatashita M. Development of a real-time imaging system for hypoxic cell apoptosis. Mol Ther Methods Clin Dev. 2016 Mar 2;5:16009. 26966700 NCP, Hypoxia Probe
Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M. Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat Commun. 2016 Mar 18;7:11030. 26988023 NCP
Miyamoto D, Nakazawa K. Differentiation of mouse iPS cells is dependent on embryoid body size in microwell chip culture. J Biosci Bioeng. 2016 Apr 16. 27090344 Hypoxia Probe
Obara C, Tomiyama KI, Takizawa K, Islam R, Yasuda T, Gotoh T, Tajima K. Characteristics of three-dimensional prospectively isolated mouse bone marrow mesenchymal stem/stromal cell aggregates on nanoculture plates. Cell Tissue Res. 2016 Apr 21. 27100525 NCP
Ota I, Masui T, Kurihara M, Yook JI, Mikami S, Kimura T, Shimada K, Konishi N, Yane K, Yamanaka T, Kitahara T. Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells. Oncol Rep. 2015 Oct 26. 26498709
Zhou, Y., Fujisawa, I., Ino, K., Matsue, T., & Shiku, H. Metabolic suppression during mesodermal differentiation of embryonic stem cells identified by single-cell comprehensive gene expression analysis. Mol Biosyst. 2015 Sep;11(9):2560-7 26211925 SD4X
Horman, S. R., Hogan, C., Reyes, K. D., Lo, F., & Antczak, C. Challenges and opportunities toward enabling phenotypic screening of complex and 3D cell models. Future medicinal chemistry, 2015, 7.4: 513-525. NCP(Review: 3D method)
Cesarz, Z., & Tamama, K. Spheroid Culture of Mesenchymal Stem Cells. Stem Cells International, 2015. NCP(Review: 3D method)
Yarar D, Lahdenranta J, Kubasek W, Nielsen UB, MacBeath G. Heregulin-ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells. Mol Cancer Ther. 2015 Sep;14(9):2072-80 26116360
Lee, J., Galloway, R., Grandjean, G., Jacob, J., Humphries, J., Bartholomeusz, C., … & Rao, A. Comprehensive Two-and Three-Dimensional RNAi Screening Identifies PI3K Inhibition as a Complement to MEK Inhibitor AS703026 for Combination Treatment of Triple-Negative Breast Cancer. Journal of Cancer, 6(12), 1306-1319. NCP
Bachmann, A., Moll, M., Gottwald, E., Nies, C., Zantl, R., Wagner, H., … & Nussler, A. K. 3D Cultivation Techniques for Primary Human Hepatocytes. Microarrays 4.1 (2015): 64-83. NCP(Review: 3D method)
Martinez NJ, Titus SA, Wagner AK, Simeonov A. High-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional models. Expert Opin Drug Discov. 2015 Sep 22:1-15. 26394277 NCP(Review: 3D method)
Kearns JD, Bukhalid R, Sevecka M, Tan G, Gerami-Moayed N, Werner SL, Kohli N, Burenkova O, Sloss CM, King AM, Fitzgerald JB, Nielsen UB, Wolf BB. Enhanced Targeting of the EGFR Network with MM-151, an Oligoclonal Anti-EGFR Antibody Therapeutic. Mol Cancer Ther. 2015 Jul;14(7):1625-36. 25911688 NCP
Dimas K, Tsimplouli C, Houchen C, Pantazis P, Sakellaridis N, Tsangaris GT, Anastasiadou E, Ramanujam RP. An Ethanol Extract of Hawaiian Turmeric: Extensive In Vitro Anticancer Activity Against Human Colon Cancer Cells. Altern Ther Health Med. 2015;21 Suppl 2:46-54. 26308760 NCP
Das V, Bruzzese F, Konečný P, Iannnell F, Budillon A, Hajdúch M. Pathophysiologically relevant in vitro tumor models for drug screening. Drug Discov Today. 2015 Apr 20. 25908576 NCP(Review: 3D method)
Yamada T, Abei M, Danjoh I, Shirota R, Yamashita T, Hyodo I, Nakamura Y. Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib. BMC Cancer. 2015 Apr 11;15(1):260. 25885470 NCP and NCM-R
Sakamoto R, Rahman MM, Shimomura M, Itoh M, Nakatsura T. Time-Lapse Imaging Assay Using the Biostation CT: A Sensitive Drug-Screening Method for 3D Cell Culture. Cancer Sci. 2015 Apr 9. 25865675 NCP
Sakamoto R, Rahman MM, Shimomura M, Itoh M, Nakatsura T. Time-Lapse Imaging Assay Using the Biostation CT: A Sensitive Drug-Screening Method for 3D Cell Culture. Cancer Sci. 2015 Apr 9. 25865675 NCP
Horman SR, Hogan C, Reyes KD, Lo F, Antczak C. Challenges and opportunities toward enabling phenotypic screening of complex and 3D cell models. Future Med Chem. 2015 Mar;7(4):513-25. 25875876 NCP(Review: 3D method)
Doi N, Ogawa R, Cui ZG, Morii A, Watanabe A, Kanayama S, Yoneda Y, Kondo T. The acquired radioresistance in HeLa cells under conditions mimicking hypoxia was attenuated by a decreased expression of HIF subunit genes induced by RNA interference. Exp Cell Res. 2015 Mar 21. pii: S0014-4827(15)00094-4. 25805230 NCP
Rosenberg SA, Niglio SA, Salehomoum N, Chan JL, Jeong BS, Wen Y, Li J, Fukui J, Chen S, Shin SS, Goydos JS. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Transl Oncol. 2015 Feb;8(1):1-9. 25749171 NCP and NCM
Yoshii Y, Furukawa T, Waki A, Okuyama H, Inoue M, Itoh M, Zhang MR, Wakizaka H, Sogawa C, Kiyono Y, Yoshii H, Fujibayashi Y, Saga T. High-throughput screening with nanoimprinting 3D culture for efficient drug development by mimicking the tumor environment Biomaterials 51 (2015) Volume 51, May 2015, 278-289 25771018 NCP
Anastasia Bachmann, Matthias Moll, Eric Gottwald, Cordula Nies, Roman Zantl, Helga Wagner, Britta Burkhardt, Juan J. Martínez Sánchez, Ruth Ladurner, Wolfgang Thasler, Georg Damm, Andreas K. Nussler 3D Cultivation Techniques for Primary Human Hepatocytes Microarrays 2015, 4, 64-83 NCP(Review: 3D method)
Imamura Y, Mukohara T, Shimono Y, Funakoshi Y, Chayahara N, Toyoda M, Kiyota N, Takao S, Kono S, Nakatsura T, Minami H. Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer. Oncol Rep. 2015 Jan 29. 25634491 NCP
Kinouchi M, Uchida D, Kuribayashi N, Tamatani T, Nagai H, Miyamoto Y Involvement of miR-518c-5p to growth and metastasis in oral cancer. PLoS One. 2014 Dec 23;9(12):e115936 25536052 NCP
Lamhamedi-Cherradi SE, Santoro M, Ramammoorthy V, Menegaz BA, Bartholomeusz G, Iles LR, Amin HM, Livingston JA, Mikos AG, Ludwig JA. 3D tissue-engineered model of Ewing’s sarcoma. Adv Drug Deliv Rev. 2014 Dec 15;79-80:155-71. 25109853 NCP
Saar M, Zhao H, Nolley R, Young SR, Coleman I, Nelson PS, Vessella RL, Peehl DM. Spheroid culture of LuCaP 147 as an authentic preclinical model of prostate cancer subtype with SPOP mutation and hypermutator phenotype. Cancer Lett. 2014 Sep 1;351(2):272-80. 24998678 NCP
Matsuda Y, Yoshimura H, Suzuki T, Uchida E, Naito Z, Ishiwata T. Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic cancer. Cancer Sci. 2014 Sep;105(9):1212-9. 24975163 NCP
Zhang X, Nan Z, Li C, Gao K. Cytotoxic effect of ergot alkaloids in Achnatherum inebrians infected by the Neotyphodium gansuense endophyte. J Agric Food Chem. 2014 Jul 30;62(30):7419-22. 24851700 NCP
Takeuchi H, Nakatsuji N, Suemori H. Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture. Sci Rep. 2014 Mar 27;4:4488. 24671046 SLB
Yamamoto M, Kawashima N, Takashino N, Koizumi Y, Takimoto K, Suzuki N, Saito M, Suda H. Three-dimensional spheroid culture promotes odonto/osteoblastic differentiation of dental pulp cells Arch Oral Biol. 2014 Mar;59(3):310-7 Hypoxia Probe
Aronchik I, Appleton BA, Basham S, Crawford K, Del Rosario M, Doyle LV, Estacio WF, Lan J, Lindvall MK, Luu CA, Ornelas E, Venetsanakos E, Shafer CM, Jefferson AB. Novel Potent and Selective Inhibitors of p90 Ribosomal S6 Kinase Reveal the Heterogeneity of RSK Function in MAPK Driven Cancers. Mol Cancer Res. 2014 Feb 19. [Epub ahead of print] 24554780 NCP
Elsayed M, Merkel OM. Nanoimprinting of topographical and 3D cell culture scaffolds. Nanomedicine (Lond). 2014 Feb;9(2):349-66. 24552565 NCP(Review: 3D method)
Aritomi K, Ishitsuka Y, Tomishima Y, Shimizu D, Abe N, Shuto T, Irikura M, Kai H, Irie T. Evaluation of Three-Dimensional Cultured HepG2 Cells in a Nano Culture Plate System: an In Vitro Human Model of Acetaminophen Hepatotoxicity. J Pharmacol Sci. 2014 Feb 19;124(2):218-29. 24492462 NCP
Fitzgerald JB, Johnson BW, Baum J, Adams S, Iadevaia S, Tang J, Rimkunas V, Xu L, Kohli N, Rennard R, Razlog M, Jiao Y, Harms BD, Olivier KJ Jr, Schoeberl B, Nielsen UB, Lugovskoy AA. MM-141, an IGF-IR- and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors. Mol Cancer Ther. 2014 Feb;13(2):410-25. 24282274 NCP
Chiba T, Suzuki E, Yuki K, Zen Y, Oshima M, Miyagi S, Saraya A, Koide S, Motoyama T, Ogasawara S, Ooka Y, Tawada A, Nakatsura T, Hayashi T, Yamashita T, Kaneko S, Miyazaki M, Iwama A, Yokosuka O. Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners. PLoS One. 2014 Jan 13;9(1):e84807. 24454751 NCP
Xiao L, Tsutsui T. Characterization of human dental pulp cells-derived spheroids in serum-free medium: stem cells in the core. J Cell Biochem. 2013 Nov;114(11):2624-36. 23794488 Hypoxia Probe
Li Z, Cui Z. Three-dimensional perfused cell culture. Biotechnol Adv. 2013 Oct 29. pii: S0734-9750(13)00183-3. 24184152 NCP(Review: 3D method)
Takahashi RU, Takeshita F, Honma K, Ono M, Kato K, Ochiya T. Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β. Sci Rep. 2013 Aug 20;3:2474. 23959174 NCP
Arai K, Sakamoto R, Kubota D, Kondo T. Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system. Proteomics. 2013 Aug;13(15):2351-60. 23712969 NCP
Spivak-Kroizman TR, Hostetter G, Posner R, Aziz M, Hu C, Demeure MJ, Von Hoff D, Hingorani SR, Palculict TB, Izzo J, Kiriakova GM, Abdelmelek M, Bartholomeusz G, James BP, Powis G. Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res. 2013 Jun 1;73(11):3235-47. 23633488 NCP
Martin ES, Belmont PJ, Sinnamon MJ, Richard LG, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji X, Xie Z, Xie T, Lamb J, Weinrich SL, VanArsdale T, Bronson RT, Xavier RJ, Vander Heiden MG, Kan JL, Mahmood U, Hung KE. Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. Clin Cancer Res. 2013 Jun 1;19(11):2929-40. 23403635 NCP
Fujiwara D, Kato K, Nohara S, Iwanuma Y, Kajiyama Y. The usefulness of three-dimensional cell culture in induction of cancer stem cells from esophageal squamous cell carcinoma cell lines. Biochem Biophys Res Commun. 2013 May 17;434(4):773-8. 23602898 NCP
Yamagishi N, Teshima-Kondo S, Masuda K, Nishida K, Kuwano Y, Dang DT, Dang LH, Nikawa T, Rokutan K. Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells. BMC Cancer. 2013 May 7;13:229. 23651517 NCP
Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H,Nakagawa T, Saya H, Nagano O. xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma. Cancer Res. 2013 Mar 15;73(6):1855-66. 23319806 NCP
Yabuta N, Mukai S, Okamoto A, Okuzaki D, Suzuki H, Torigata K, Yoshida K, Okada N, Miura D, Ito A, Ikawa M, Okabe M, Nojima H. N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability. J Cell Sci. 2013 Jan 15;126(Pt 2):508-20. 23230145 NCP
Hashimoto M, Toshima H, Yonezawa T, Kawai K, Iijima M, Endo K. Evaluation of Silver Nanoparticle Toxicity to RAW264.7 Cells in a Three-Dimensional Cell Culture J Biomater Tissue Eng. 2013 Jan ;4(1):51-58. NCP
Bressan E, Carraro A, Ferroni L, Gardin C, Sbricoli L, Guazzo R, Stellini E, Roman M, Pinton P, Sivolella S, Zavan B Nanotechnology to drive stem cell commitment Nanomedicine. 2013;8(3):469-486.
Miyagawa Y, Okita H, Kiyokawa N Induction of adipogenic differentiation in three-dimensional culture model on a novel microfabricated scaffold Methods in Molecular Biology. 2013;952:pp 275-286 NCP
Rimann M, Graf-Hausner U. Synthetic 3D multicellular systems for drug development. Curr Opin Biotechnol. 2012 Oct;23(5):803-9. 22326911 NCP(Review: 3D method)
Murakami A, Yakabe K, Yoshidomi K, Sueoka K, Nawata S, Yokoyama Y, Tsuchida S, Al-Mulla F, Sugino N. Decreased carbonyl reductase 1 expression promotes malignant behaviours by induction of epithelial mesenchymal transition and its clinical significance. Cancer Lett. 2012 Oct 1;323(1):69-76. 22542806 NCP
Karlsson H, Fryknas M, Larsson R, Nygren P. Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system. Exp Cell Res. 2012 Aug 1;318(13):1577-85. 22487097 NCP
Suhail MM, Wu W, Cao A, Mondalek FG, Fung KM, Shih PT, Fang YT, Woolley C, Young G, Lin HK. Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells. BMC Complement Altern Med. 2011 Dec 15;11:129. 22171782 NCP
Nakamura K, Kato N, Aizawa K, Mizutani R, Yamauchi J, Tanoue A. Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold. J Toxicol Sci. 2011 Oct;36(5):625-33. 22008537 NCP
Matsuda Y, Ishiwata T, Yamahatsu K, Kawahara K, Hagio M, Peng WX, Yamamoto T, Nakazawa N, Seya T, Ohaki Y, Naito Z. Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: a potential therapeutic target in colorectal cancer. Cancer Lett. 2011 Oct 28;309(2):209-19. 21745712 NCP
Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, Kuroda Y, Kiyono Y, Yoshii H, Furukawa T, Asai T, Okazawa H, Gelovani JG, Fujibayashi Y. The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation. Biomaterials. 2011 Sep;32(26):6052-8. 21640378 NCP
Ishiwata T, Teduka K, Yamamoto T, Kawahara K, Matsuda Y, Naito Z. Neuroepithelial stem cell marker nestin regulates the migration, invasion and growth of human gliomas. Oncol Rep. 2011 Jul;26(1):91-9. 21503585 NCP
Koh MY, Lemos R Jr, Liu X, Powis G. The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res. 2011 Jun 1;71(11):4015-27. 21512133 NCP
Matsuda Y, Kawamoto Y, Teduka K, Peng WX, Yamamoto T, Ishiwata T, Naito Z. Morphological and cytoskeletal alterations of nervous system tumor cells with different culturing methods. Int J Oncol. 2011 May;38(5):1253-8. 21331444 NCP
Matsuda Y, Ishiwata T, Naito Z. Immunocytochemical Analysis of a Three-dimensional Spheroidal Culture System J Nippon Med Sch 2011;78(4):206-7 NCP
Miyagawa Y, Okita H, Hiroyama M, Sakamoto R, Kobayashi M, Nakajima H, Katagiri YU, Fujimoto J, Hata J, Umezawa A, Kiyokawa N. A microfabricated scaffold induces the spheroid formation of human bone marrow-derived mesenchymal progenitor cells and promotes efficient adipogenic differentiation. Tissue Eng Part A. 2011 Feb;17(3-4):513-21. 20818998 NCP
Matsuda Y, Ishiwata T, Kawamoto Y, Kawahara K, Peng WX, Yamamoto T, Naito Z. Morphological and cytoskeletal changes of pancreatic cancer cells in three-dimensional spheroidal culture. Med Mol Morphol. 2010 Dec;43(4):211-7. 21267697 NCP
Uchida Y, Tanaka S, Aihara A, Adikrisna R, Yoshitake K, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Irie T, Kudo A, Nakamura N, Lai PB, Arii S. Analogy between sphere forming ability and stemness of human hepatoma cells. Oncol Rep. 2010 Nov;24(5):1147-51. 20878104 NCP
Fukuda M, Sakashita H Expression of hypoxia-inducible factor-1a in squamous cell carcinoma of the oral cavity. Hosp Dent (Tokyo). 2009;21(2):85-90. NCP
Mizushima H, Wang X, Miyamoto S, Mekada E. Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures. J Cell Sci. 2009 Dec 1;122(Pt 23):4277-86. 19887590 NCP
Ishihara M, Iwasa M, Doshida M, Kikuchi M Cellular functional image using hyperspectral technology for application to regenerative medicine Proc. of SPIE 2009 Feb 23;7179:71790E NCP